Results: The dose of 0.2 g/100 ml was the minimum dose that killed 100% of larvae of Anopheles aconitus (p = 0.01). The LD 50 and LD 90 were analyzed using Probit analysis. The data obtained were analyzed by the Kruskal-Wallis statistical test. Assessment by counting number of mortality larvae and the number of live larvae from each treatment was compared to the control. Air temperature and water pH were controlled during observation. The research was conducted at Laboratory of Parasitology, Faculty of Medicine, Universitas Islam Sultan Agung, Semarang. Methods: A true experimental study with a post test only control group design, the object of research was Anopheles aconitus Instar III larvae. Study aims to determine effect of mindi leaf powder ( Melia azedarach L) on mortality of Anopheles aconitus instar III larvae. Mindi tree contains Azadiractin compounds which are larvicides. Efforts to control malaria can be carried out in various ways, starting from treatment, prevention, to breaking the transmission chain through vectors, both mosquitoes and larvae. Background: Malaria is a disease caused by Plasmodium parasite infection wwhich is transmitted through bite of an Anopheles mosquito.
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